Chemical Constituents, <i>in vitro</i> Antioxidant and Antiproliferative Activities of <i>Perralderia coronopifolia</i> Coss. subsp eu-<i>coronopifolia</i> M. var. <i>typica</i> M. extract

Boussaha S., Bekhouche K., Boudjerda A., Leon F., Koldas S., Yaglioglu A. S., ...More

RECORDS OF NATURAL PRODUCTS, no.3, pp.312-322, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2015
  • Journal Name: RECORDS OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.312-322
  • Ondokuz Mayıs University Affiliated: No

Abstract

Phytochemical investigations of extracts from the aerial parts (leaves and flowers) of Perralderia coronopifolia Cosson resulted in the isolation of nine secondary metabolites corresponding to three flavonoids: rhamnazin (1), chrysosplenol D (3), and (2R, 3R) taxifolin (4), two monoterpene glycosides : myrtenol-beta-D-glucopyranoside- 6'-O-acetate (2) and myrtenol beta-D-glucopyranoside (7), a disaccharide: sucrose (9) and three di-O-caffeoylquinic acid derivatives : methyl 3, 5-di-O-caffeoyl quinate (5) and methyl 3,4-di-O-caffeoyl quinate (6) as a mixture and 1,5-di-O-caffeoylquinic acid (8). The structures were identified by spectroscopic methods such as 114 and C-13 NMR, COSY, HSQC and HMBC experiments, HRESI-MS and comparison with literature data. Myrteno1-beta-Dglucopyranoside-6'-O-acetate (2) was isolated in pure and native state for the first time. The other compounds are new for the genus Perralderia Cosson. The ethyl acetate extract showed a high antioxidant effect, especially DPPH radical scavenging activity with IC50=7.01 +/- 0.28 mu g/mL) compared to ascorbic acid (IC50= 5 +/- 0.1 mu g/mL. This extract also showed antiproliferative activity against HeLa (human cervix carcinoma) and C6 (rat brain tumor) cells.