Eculizumab therapy in a patient with dense-deposit disease associated with partial lipodystropy

Ozkaya O., Nalçacıoğlu H., Tekcan Karalı D., Genc G., Can Meydan B., ÖZDEMİR B. H., ...Daha Fazla

PEDIATRIC NEPHROLOGY, cilt.29, sa.7, ss.1283-1287, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00467-013-2748-5
  • Dergi Adı: PEDIATRIC NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1283-1287
  • Anahtar Kelimeler: Dense deposit disease, Complement alternative pathway, C3 nephritic factor, Eculizumab, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, C3 GLOMERULOPATHY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Dense deposit disease (DDD) (also known as membranoproliferative glomerulonephritis type II) in childhood is a rare glomerulonephritis with frequent progression to end-stage renal disease (ESRD) and a high recurrence after kidney transplantation. The pathophysiologic basis of DDD is associated with the uncontrolled systemic activation of the alternative pathway (AP) of the complement cascade.