Studies on Oxidative Cleavage Activity and DNA-Binding of Zinc Complexes with Diaqua<i>bis</i>(N,N-diethylenenicotinamide)<i>bis</i>(salicylato) and Diaqua<i>bis</i>(N,N-diethylnicotinamide)<i>bis</i>(4-nitrobenzoato)

Arslantas A., ERGÜN M. Y., SÖZMEN M.

ASIAN JOURNAL OF CHEMISTRY, sa.10, ss.7648-7654, 2010 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2010
  • Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7648-7654
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

The oxidative cleavage and binding of cat DNA with the Zn(II) complexes of diaquabis(N,N-diethylenenicotinamide)bis(salicylato) and diaquabis(N,N-diethylnicotinamide)bis(4-nitrobenzoato), in an aqueous solutions at pH 7.0, have been investigated as a function of the metal complex-DNA by UV absorption spectrophotometry, viscosity and electrophoresis measurments. In this study, the interactions were compared between DNA and the two zinc(II) complexes. The gel electrophoresis study showed that both of complexes cleaved the cat DNA under physiological conditions in the presence of H(2)O(2). Absorption spectroscopy and viscosity measurement indicate that the complexes bind to DNA by intercalative binding modes. The results confirm for an intercalative interaction of both complex 1 and 2 with DNA, showing complex 1 has more affinity than complex 2.