Two new zinc(II) and mercury(II) complexes based on N,V-(cyclohexane-1,2-diylidene)bis(4-fluorobenzohydrazide): synthesis, crystal structures and antibacterial activities

OmarAli A. B., Al-Karawi A. J. M., Awad A. A., DEGE N., Kansiz S., Ağar E., ...More

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, vol.76, pp.476-496, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76
  • Publication Date: 2020
  • Doi Number: 10.1107/s2053229620004994
  • Journal Name: ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, EMBASE, INSPEC, MEDLINE
  • Page Numbers: pp.476-496
  • Keywords: bisaroylhydrazones, tetrahedral zinc(II), antibacterial activity, crystal structure, mercury(II), TRANSITION-METAL-COMPLEXES, ANTIOXIDANT ACTIVITY, SCHIFF-BASE, HYDRAZONE, LIGAND, COPPER(II), KINETICS, NI(II), CU(II)
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Reaction of N,N1-(cyclohexane-1,2-diylidene)bis(4-fluorobenzohydrazide), C20H18F2N402, (LF), with zinc chloride and mercury(II) chloride produced different types and shapes of neutral coordination complexes, namely, dichlorido[N,AP(cyclohexane-1,2-cliylidene)bis(4-fluorobenzohydrazide)-K2N,01zinc(II), [ZnC12(C(20)H(18)F2N402)], (1), and dichlorido[N,AP-(cyclohexane-1,2-diylidene)bis(4fluorobenzohydrazide)-K40,N,AP,011mercury(II), [HgC12(C20H18F2N402)], (2). The organic ligand and its metal complexes are characterized using various techniques: IR, UV Vis and nuclear magnetic resonance (NMR) spectroscopies, in addition to powder X-ray diffraction (PXRD), single -crystal X-ray crystallography and microelemental analysis. Depending upon the data from these analyses and measurements, a typical tetrahedral geometry was confirmed for zinc complex (1), in which the ZnIT atom is located outside the bis(benzhydrazone) core. The Hg" atom in (2) is found within the core and has a common octahedral structure. The in vitro antibacterial activities of the prepared compounds were evaluated against two different bacterial strains, i.e. gram positive Bacillus subtilis and gram negative Pseudomonas aeruginosa bacteria. The prepared compounds exhibited differentiated growth -inhibitory activities against these two bacterial strains based on the difference in their lipophilic nature and structural features.