Design, Synthesis, and In vitro Evaluation of Thieno[a]dibenzothiophene Derivatives

Konuş M., Algso M. A. S., Kavak E., Kurt Kızıldoğan A., Yılmaz C., Kivrak A.

CHEMISTRYSELECT, vol.5, no.12, pp.3700-3709, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 12
  • Publication Date: 2020
  • Doi Number: 10.1002/slct.202000685
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.3700-3709
  • Keywords: antibacterial, antifungal, cascade reaction, electrophilic cyclization, thieno[a]dibenzothiophenes, ELECTROPHILIC CYCLIZATION, ANTIOXIDANT ACTIVITY, CASCADE CYCLIZATION, FACILE SYNTHESIS, THIOPHENE, INHIBITORS, PYRAZOLES, CYTOCHROME-P450, ARYLDIYNES, DISCOVERY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

A variety of highly substituted thieno[2,3-a]dibenzothiophenes and thieno[3,2-a]dibenzothiophenes are readily prepared via cascade electrophilic cyclization reaction. The reaction was tolerated a variety of compounds. In the present study, antimicrobial and antifungal activities were investigated for all synthesized molecules against A. niger ATCC 16404, C. albicans ATCC 10231, S. aureus ATCC 25923 and B. subtilis ATCC 6633, respectively.