Voltammetric, Spectroscopic and Thermal Investigations of the Interaction of Levofloxacin with Cysteine at Physiological pH

Biçer E., Nuertayi P.

RUSSIAN JOURNAL OF ELECTROCHEMISTRY, vol.53, no.5, pp.469-478, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1134/s1023193517050044
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.469-478
  • Keywords: levofloxacin, cysteine, interaction, voltammetry, spectroscopy, thermal analysis, BOVINE SERUM-ALBUMIN, CARBON-PASTE ELECTRODE, FLUOROQUINOLONES, BINDING, OFLOXACIN, COMPLEX
  • Ondokuz Mayıs University Affiliated: Yes


In this study, levofloxacin (LEVOF) hemihydrate interaction with L-cysteine (RSH) was investigated by using square-wave voltammetry (SWV) in Britton-Robinson (B-R) buffer pH 7.4. Addition of the LEVOF to RSH solution resulted in dropping of the main reduction peak current of RSH (the current of mercurous cysteine thiolate Hg-2(RS)(2)). The vary in the peak current of Hg-2(RS)(2), after the adding of the LEVOF is indicated an interaction between RSH and LEVOF molecules. Moreover, the interaction between two molecules also confirmed with UV-Vis, FT-IR spectroscopic measurements and thermal analysis data. Binding constant of LEVOF with RSH was calculated by both voltammetric and UV-Vis spectroscopic data.