Estrogen Receptor 1 Gene rs22346939 and rs9340799 Variants are Associated with Major Depressive Disorder and its Clinical Features

Ozsoy F., NURSAL A. F., KARAKUŞ N., Demir M. O., YİĞİT S.

CURRENT NEUROVASCULAR RESEARCH, cilt.18, sa.1, ss.12-19, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1567202618666210531122239
  • Dergi Adı: CURRENT NEUROVASCULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.12-19
  • Anahtar Kelimeler: Estrogen receptor 1, major depressive disorder, variant, rs22346939, rs9340799, PCR-RFLP, ALPHA GENE, ESR1 POLYMORPHISMS, ANXIETY, WOMEN, SUSCEPTIBILITY, ENDOMETRIOSIS, METAANALYSIS, DENSITY, CANCER
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Major Depressive Disorder (MDD) is a major health problem worldwide. Estrogen interacts with the central nervous system and has been shown to affect anxiety and depressive behavior. Estrogen mediates its effects by connecting its receptors, estrogen receptors 1 and 2. The purpose of this case-control study was to clarify the association between MDD risk and estrogen receptor 1 (ESR1) gene variants.