Dermanyssus gallinae is a hematophagous ectoparasite responsible for anaemia, weight loss, itching, dermatitis, and also decreased egg production in many domestic and wild bird species. The use of various synthetic acaricides such as avermectin and isoxazoline group is common in its treatment. This study aimed to compare the efficacy of Selamectin and Fluralaner on canaries during D. gallinae infestations. In the study, all canaries before treatment constituted the control group. Two groups of canaries were included in the study (n:40): Selamectin was applied to the first group (n:20) and Fluralaner to the second group (n:20). Selamectin was applied topically and infrascapularly at a 20 mg/kg dose, while Fluralaner was administered orally by a dose of 0.5 mg/kg. Parasite load was evaluated before and after treatment. With regard to the reduction in the mean number of red mites, the treatment successes of Selamectin and Fluralaner were evaluated as percentages of the efficacy. The percentage of efficacy of Selamectin and Fluralaner treatments were 80.0%, and 90.90%, respectively. We conclude that both drugs provide effective treatment in the treatment of D. gallinae infestation in canaries, nevertheless short-term clinical efficacy of Fluralaner was superior to Selamectin.