Association of interleukin-10 gene polymorphisms with severe generalized chronic periodontitis

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Sumer A. P., Kara N., Keles G. C., Güneş S., Koprulu H., Bagci H.

JOURNAL OF PERIODONTOLOGY, cilt.78, sa.3, ss.493-497, 2007 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 78 Sayı: 3
• Basım Tarihi: 2007
• Doi Numarası: 10.1902/jop.2007.060309
• Dergi Adı: JOURNAL OF PERIODONTOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.493-497
• Anahtar Kelimeler: chronic periodontitis, cytokines, genetic polymorphism, interleukin-10, periodontal disease, PROMOTER POLYMORPHISMS, JAPANESE PATIENTS, VITAMIN-D, RISK-FACTORS, DISEASE, IL-10, PROGRESSION, ALLELE, ADULT
• Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Interleukin-10 (IL-10), an anti-inflammatory cytokine, plays a role in periodontal disease by inhibiting synthesis of proinflammatory cytokines and stimulating protective antibody production. Genetic polymorphisms in the IL-10 gene might be useful as a marker to diagnose susceptibility to periodontitis. Therefore, the aim of this study was to investigate the association between IL-10 gene polymorphisms and severe generalized chronic periodontitis (CP) in a Turkish population.