Association of interleukin-10 gene polymorphisms with severe generalized chronic periodontitis
JOURNAL OF PERIODONTOLOGY, cilt.78, sa.3, ss.493-497, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 3
- Basım Tarihi: 2007
- Doi Numarası: 10.1902/jop.2007.060309
- Dergi Adı: JOURNAL OF PERIODONTOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.493-497
- Anahtar Kelimeler: chronic periodontitis, cytokines, genetic polymorphism, interleukin-10, periodontal disease, PROMOTER POLYMORPHISMS, JAPANESE PATIENTS, VITAMIN-D, RISK-FACTORS, DISEASE, IL-10, PROGRESSION, ALLELE, ADULT
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background: Interleukin-10 (IL-10), an anti-inflammatory cytokine, plays a role in periodontal disease by inhibiting synthesis of proinflammatory cytokines and stimulating protective antibody production. Genetic polymorphisms in the IL-10 gene might be useful as a marker to diagnose susceptibility to periodontitis. Therefore, the aim of this study was to investigate the association between IL-10 gene polymorphisms and severe generalized chronic periodontitis (CP) in a Turkish population.