Lack of association of the CD14/C-159T polymorphism with susceptibility and progression parameters in Turkish multiple sclerosis patients

Kurne, Asli; Sayat, Guliz; Aydin, Omer; Turgutoglu, Nihan; Terzi, Murat; Sackesen, Cansin; KARABULUT, ERDEM; Karabudak, Rana

doi:10.1016/j.jneuroim.2012.05.005

Lack of association of the CD14/C-159T polymorphism with susceptibility and progression parameters in Turkish multiple sclerosis patients

Kurne A., Sayat G., Aydin O. F., Turgutoglu N., Terzi M., Sackesen C., ...Daha Fazla

JOURNAL OF NEUROIMMUNOLOGY, cilt.250, sa.1-2, ss.83-86, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 250 Sayı: 1-2
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.jneuroim.2012.05.005
Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.83-86
Anahtar Kelimeler: Multiple sclerosis, RRMS, Soluble CD14, CD14 polymorphism, Progression index, SOLUBLE CD14, GENE, DISABILITY, RECEPTOR, PROMOTER, BLOOD
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Soluble (s) CD14, being a receptor for lipopolysaccharides (LPSs) may inhibit LPS-triggered apoptosis and T lymphocyte proliferation. C to T exchange at position - 159 in the promoter region of the CD14 gene might lead to higher sCD14 levels.