Lack of association of the CD14/C-159T polymorphism with susceptibility and progression parameters in Turkish multiple sclerosis patients

Kurne, Asli; Sayat, Guliz; Aydin, Omer; Turgutoglu, Nihan; Terzi, Murat; Sackesen, Cansin; KARABULUT, ERDEM; Karabudak, Rana

doi:10.1016/j.jneuroim.2012.05.005

Lack of association of the CD14/C-159T polymorphism with susceptibility and progression parameters in Turkish multiple sclerosis patients

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Kurne A., Sayat G., Aydin O. F., Turgutoglu N., Terzi M., Sackesen C., ...More

JOURNAL OF NEUROIMMUNOLOGY, vol.250, no.1-2, pp.83-86, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 250 Issue: 1-2
Publication Date: 2012
Doi Number: 10.1016/j.jneuroim.2012.05.005
Journal Name: JOURNAL OF NEUROIMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.83-86
Keywords: Multiple sclerosis, RRMS, Soluble CD14, CD14 polymorphism, Progression index, SOLUBLE CD14, GENE, DISABILITY, RECEPTOR, PROMOTER, BLOOD
Ondokuz Mayıs University Affiliated: Yes

Abstract

Soluble (s) CD14, being a receptor for lipopolysaccharides (LPSs) may inhibit LPS-triggered apoptosis and T lymphocyte proliferation. C to T exchange at position - 159 in the promoter region of the CD14 gene might lead to higher sCD14 levels.