Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population

Kara N., Senturk N., Güneş S., Bagci H., Yiğit S., Turanli A.

ARCHIVES OF DERMATOLOGICAL RESEARCH, vol.297, no.10, pp.468-471, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 297 Issue: 10
  • Publication Date: 2006
  • Doi Number: 10.1007/s00403-006-0643-7
  • Journal Name: ARCHIVES OF DERMATOLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.468-471
  • Keywords: Behcet's disease, nitric oxide synthase, eNOS gene polymorphism, VARIANT
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behcet's disease (BD). This study investigated the relationship of the eNOS Glu(298) --> Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT=58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P=0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR=0.91, 95% CI (0.55-1.50), P=0.690]. Glu(298) --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.