Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population

Kara N., Senturk N., Güneş S., Bagci H., Yiğit S., Turanli A.

ARCHIVES OF DERMATOLOGICAL RESEARCH, cilt.297, sa.10, ss.468-471, 2006 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 297 Sayı: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s00403-006-0643-7
  • Dergi Adı: ARCHIVES OF DERMATOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.468-471
  • Anahtar Kelimeler: Behcet's disease, nitric oxide synthase, eNOS gene polymorphism, VARIANT
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behcet's disease (BD). This study investigated the relationship of the eNOS Glu(298) --> Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT=58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P=0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR=0.91, 95% CI (0.55-1.50), P=0.690]. Glu(298) --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.