Promoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer
ONCOTARGETS AND THERAPY, cilt.11, ss.4189-4196, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11
- Basım Tarihi: 2018
- Doi Numarası: 10.2147/ott.s158259
- Dergi Adı: ONCOTARGETS AND THERAPY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4189-4196
- Anahtar Kelimeler: biomarker, CDH1, urine cytology, urothelial bladder cancer, p14ARF, urine, E-CADHERIN GENE, DNA METHYLATION, MULTIPLE GENES, TUMOR-TISSUES, RASSF1A GENES, VOIDED URINE, HYPERMETHYLATION, BIOMARKERS, P16, ARF
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background/aim: Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests in our population.