Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival

Karacaoglan N., Akbas H.

Otolaryngology - Head and Neck Surgery, cilt.120, sa.2, ss.272-274, 1999 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0194-5998(99)70419-5
  • Dergi Adı: Otolaryngology - Head and Neck Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.272-274
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Flap necrosis is still a significant complication in all types of flap surgery. The Effect of parenteral pentoxifylline and nitroglycerin in improving survival of ischemic skin flaps was tested in Wistar rats. In the control group (n = 15) the mean viable length of the flaps was calculated to be 6.160 ± 0.936, and nonnecrotic flap area was found to be 1859.1 ± 269.3. In the group treated with pentoxifylline and nitroglycerin (n = 15), the mean viable length of the flap was calculated to be 6.907 ± 0.617, and the mean nonnecrotic flap area was found to be 2078.5 ± 172.7. In this study results showed that the use of parenteral pentoxifylline and topical nitroglycerin is effective on skin flap survival.