Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase

Gecibesler Ý. H., DAYAN O., Şerbetçi Z., Demirtas İ.

Pharmaceutical Chemistry Journal, vol.53, no.10, pp.914-920, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1007/s11094-020-02099-w
  • Journal Name: Pharmaceutical Chemistry Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE
  • Page Numbers: pp.914-920
  • Keywords: DPPH free radical scavenging, lipid peroxidation, organoruthenium complexes, reducing power, superoxide anion radical scavenging, xanthine oxidase
  • Ondokuz Mayıs University Affiliated: No

Abstract

Biological activities of organoruthenium complexes [chloro [N,N′-[(2,6-pyridinediyl-κN) diethylidyne] bis-[benzenamine-κN]] [N-[(2-pyridinyl-κN) methylene] benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 1), [chloro [2,2′-(2,6-pyridinediyl-κN) bis [1H-benzimidazole-κN3]][N-[(2-pyridinyl-κN) methylene] benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 2), and [chloro[2,6-di(1H-pyrazol-3-yl-κN2) pyridine-κN] [N-[(2-pyridinyl-κN) methylene] [benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 3) have been studies. The compounds were tested for in vitro biological activity on test models including 2,2-diphenyl-1-picryl-hydrazyl (DPPH) reducing power, superoxide anion radical-scavenging activity, and lipid peroxidation activity by ferric thiocyanate. It is established that Cmplx 2 with benzimidazole ligand displays significant xanthine oxidase inhibitory activity (IC50 = 53.80 ± 2.69 μM), DPPH free radical scavenging activity (79.49 ± 1.59), and superoxide anion radical scavenging activity (75.73 ± 2.85%). The coordination of benzenamine and benzenesulfanoamine ligands reduces lipid peroxidation as observed in the case of Cmplx 1 (87.17 ± 3.88%) and the higher reducing power of Cmplx 1 obtained at all concentrations. It was concluded from the test results that organoruthenium complexes showed much better antioxidant activity than expected.