Prophylactic Central Nervous System Irradiation Is Not Indispensable in Adult Patients with Acute Lymphoblastic Leukemia: A Multicenter Retrospective Cohort Study
TURKISH JOURNAL OF HEMATOLOGY, vol.39, no.3, pp.152-159, 2022 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 39 Issue: 3
- Publication Date: 2022
- Doi Number: 10.4274/tjh.galenos.2022.2021.0680
- Journal Name: TURKISH JOURNAL OF HEMATOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
- Page Numbers: pp.152-159
- Keywords: Craniospinal, Young adults, Radiation toxicity, Central nervous system relapse, Acute lymphoblastic leukemia, CHILDRENS CANCER GROUP, LIPOSOMAL CYTARABINE, RISK GROUPS, DIAGNOSIS, THERAPY, RELAPSE, CNS, CHEMOTHERAPY, METHOTREXATE, INVOLVEMENT
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Objective: Studies comparing the efficacy and safety of prophylactic regimens for central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) are scarce in adults. This multicenter retrospective study aimed to compare the efficacy of prophylactic regimens with and without CNS irradiation on the development of CNS relapse during follow-up. Materials and