The effect of IL-4 and MTHFR gene variants in ankylosing spondylitis

YİĞİT S., Inanir A., Tural Ş., Filiz B., Tekcan A.

ZEITSCHRIFT FUR RHEUMATOLOGIE, vol.74, no.1, pp.60-66, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1007/s00393-014-1403-2
  • Journal Name: ZEITSCHRIFT FUR RHEUMATOLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.60-66
  • Keywords: Methylenetetrahydrofolate reductase, Interleukin-4, Polymerase chain reaction, Homocysteine, Polymorphism, METHYLENETETRAHYDROFOLATE REDUCTASE, DISEASE-ACTIVITY, TNF-ALPHA, POLYMORPHISM, ASSOCIATION, SUSCEPTIBILITY, HOMOCYSTEINE, POPULATION, CLUSTER, RISK
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Ankylosing Spondylitis (AS) is a chronic inflammatory rheumatic disease that characteristically affects the sacroiliac joints and the spine. The exact pathogenesis of AS remains poorly understood, but genetic factors play a key role in disease development. Several genes have been consistently associated with susceptibility to AS. This study was conducted in Turkish AS patients to determine the frequency of the methylenetetrahydrofolate reductase (MTHFR) gene C677T and interleukin-4 (IL-4) gene 70 bp variable number of tandem repeats (VNTR) variants, as well as their association with clinical characteristics.