Preparation of Molecularly Imprinted Polypyrrole Modified Gold Electrode for Determination of Tyrosine in Biological Samples

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Ermis N., TINKILIÇ N.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, vol.13, no.3, pp.2286-2298, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.20964/2018.03.29
  • Journal Name: INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2286-2298
  • Keywords: molecular imprinting, imprinted polymer, polypyrrole, tyrosine, PENCIL GRAPHITE ELECTRODE, ASCORBIC-ACID, SENSOR, NANOPARTICLES, PHENYLALANINE, DOPAMINE, FILM
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this paper, a novel electrochemical sensor based on molecularly imprinted polypyrrole film at gold electrode for selective and sensitive detection of tyrosine (Tyr) was fabricated. Tyr was used as template molecule and polymerized in presence of pyrrole, used as the functional monomer. As a comparison a non-modified polymer surface was also prepared under same circumstances without template molecule. The feature of both imprinted and non-imprinted electrode surfaces were performed by cyclic voltammetry (CV), square wave voltammetry (SWV) and electro impedance spectroscopy (EIS). The imprinted polypyrrole sensor exhibited good selectivity toward tyrosine in comparison with other structurally similar molecules. Under the optimal experimental conditions, the linearity range and the detection limit of the imprinted sensor were obtained as 5.0x10(-9)-2.5x10(-8) M and 2.5x10(-9) M, respectively.