Preparation of Molecularly Imprinted Polypyrrole Modified Gold Electrode for Determination of Tyrosine in Biological Samples

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Ermis N., TINKILIÇ N.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, cilt.13, sa.3, ss.2286-2298, 2018 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.20964/2018.03.29
  • Dergi Adı: INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2286-2298
  • Anahtar Kelimeler: molecular imprinting, imprinted polymer, polypyrrole, tyrosine, PENCIL GRAPHITE ELECTRODE, ASCORBIC-ACID, SENSOR, NANOPARTICLES, PHENYLALANINE, DOPAMINE, FILM
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In this paper, a novel electrochemical sensor based on molecularly imprinted polypyrrole film at gold electrode for selective and sensitive detection of tyrosine (Tyr) was fabricated. Tyr was used as template molecule and polymerized in presence of pyrrole, used as the functional monomer. As a comparison a non-modified polymer surface was also prepared under same circumstances without template molecule. The feature of both imprinted and non-imprinted electrode surfaces were performed by cyclic voltammetry (CV), square wave voltammetry (SWV) and electro impedance spectroscopy (EIS). The imprinted polypyrrole sensor exhibited good selectivity toward tyrosine in comparison with other structurally similar molecules. Under the optimal experimental conditions, the linearity range and the detection limit of the imprinted sensor were obtained as 5.0x10(-9)-2.5x10(-8) M and 2.5x10(-9) M, respectively.