Expression of Glypican 3 in low and high grade urothelial carcinomas

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Aydin O., Yıldız L., Baris S., Dündar C., Karagöz F.

DIAGNOSTIC PATHOLOGY, cilt.10, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s13000-015-0266-4
  • Dergi Adı: DIAGNOSTIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Glypican-3, Urothelial carcinoma, Immunohistochemistry, BETA-CATENIN ACTIVATION, HEPATOCELLULAR-CARCINOMA, CELL, DYSREGULATION, MARKER
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Glypican-3 (GPC3) is an oncofetal protein which is encoded by GPC3 gene and takes role in the regulation of cell division and apoptosis. Overexpression of GPC3 has been reported in some types of cancer such as hepatocellular carcinoma (HCC), melanoma, squamous cell carcinoma of the lungs and testicular germ cell tumors. The aim of this study was to investigate the immunohistochemical expression of GPC3 in the non-neoplastic urothelium and in urothelial carcinoma (UC). We also aimed to explore the alterations in the GPC3 expression according to the grade and the invasiveness of UC.