Effectiveness of Methotrexate in Idiopathic Granulomatous Mastitis Treatment

Kehribar D. Y., Duran T. I., Polat A., Özgen M.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, no.5, pp.560-565, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2020
  • Doi Number: 10.1016/j.amjms.2020.05.029
  • Journal Name: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.560-565
  • Keywords: Idiopathic granulomatous mastitis, Steroid, Methotrexate, Remission, ERYTHEMA-NODOSUM, LOBULAR MASTITIS, THERAPY, MANAGEMENT, LESIONS, BREAST
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Idiopathic granulomatous mastitis is a rare inflammatory disease of the breast, for which there is a lack of consensus on the treatment protocol; it requires long-term follow-up and is associated with a high rate of relapse after surgical treatment. In this study, we report on the largest single-center cohort of idiopathic granulomatous mastitis treated with steroids + methotrexate. Methods: We retrospectively examined the data of 33 patients histopathologically diagnosed with idiopathic granulomatous mastitis who were evaluated by our Rheumatology or General Surgery Clinics between 2013 and 2016. Results: Of the 33 female patients (age: 38.64 +/- 6.9 years), 24 were admitted with an initial diagnosis of idiopathic granulomatous mastitis, whereas 9 were admitted after surgical treatment. Remission was achieved in 87.9% of patients with steroid + methotrexate treatment, and there were no relapses during the 24-months follow-up period. Conclusions: Steroid + methotrexate treatment is an effective and reliable method for ensuring long-term remission in patients with idiopathic granulomatous mastitis diagnosis.