Anesthetic Management of a Pediatric Patient with Leigh Syndrome

Kocamanoğlu İ. S., Sarihasan E.

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.63, no.2, pp.220-222, 2013 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/s0034-7094(13)70219-8
  • Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.220-222
  • Keywords: Leigh Disease, Anesthesia, General, Monitoring, Physiologic, Intensive Care
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background and objectives: Leigh syndrome (LS) is a rare disease caused by abnormalities of mitochondrial energy generation. The central nervous system is most frequently affected, with psychomotor underdevelopment, seizures, nystagmus, ophthalmoparesis, optic atrophy, ataxia, dystonia, or respiratory failure. Surgical and anesthetic procedures stimulate the tracheal irritability, and could exacerbate risks of aspiration, wheezing, breathing difficulties, gasping, hypoventilation, and apnea.