Seprafilm superior to Gore-Tex in the prevention of peridural fibrosis

Topsakal C., AKPOLAT N., Erol F., Ozveren M., Akdemir I., Kaplan M., ...More

JOURNAL OF NEUROSURGERY, no.2, pp.295-302, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2004
  • Doi Number: 10.3171/jns.2004.101.2.0295
  • Journal Name: JOURNAL OF NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.295-302
  • Ondokuz Mayıs University Affiliated: No

Abstract

Object. This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model. Methods. Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05). Conclusions. Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.