The effects of mobile phones on apoptosis in cerebral tissue: an experimental study on rats

Yılmaz A., Aras M., Yılmaz N., Serarslan Y., Altaş M.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, ss.992-1000, 2014 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18
  • Basım Tarihi: 2014
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.992-1000
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Abstract. – INTRODU CTION: The concern

about mobile phone effects is increasing as the

number of users increasing too. Different stud-

ies have different resul ts, so this topic is still

open to discussion. Aim of this report was to in-

vestigate the effects of the mobile phones on the

Bcl-2 gene and p53 proteins in rat brains.

MATER IALS AND METHO DS: In the study

group of 10 rats; mobile phones that spread EMW

at a frequency between 1900-2100 MHz and Specif-

ic Absorption Rate range between 0.005 W/kg and

0.288 W/kg (Dialing mode), 0.004 W/kg and 0.029

W/kg (Calling mode) were attached to rat ears for

simulating usage in daily life for 7 times a day dur-

ing 5 minutes (3 seconds dialing mode, 4 minutes

and 47 seconds of calling mode) for a four week

period. Sham group (n=10) rats were only immobi-

lized without EMW exposure. Another group of rats

(n=10) were counted as control without any appli-

cation. immunohistopathological examination was

performed for p53 and Bcl-2 expression.

RESULTS: Immunohistopathological examina-

tions revealed that the samples in the study

group had more p53 and Bcl-2 positive stained

cells and they were stained denser. In both eval-

uations, these differ ences betw een the study

and control group were found statistically signif-

icant (p < 0.003); In Bcl-2 evaluation statistically

significant difference was found between study

and sham group to (p < 0.005); however, the p53

evalu ation betwe en the st udy and the sham

group did not show any statistically significant

difference (p > 0.005).

CONCLUSIONS: Our results showed that the

electro-magnetic waves emitted by the mobile

phones may have effect on apoptosis. Besides,

obtained data revealed that more realistic appli-

cation of mobile phones during experiments is

more important as expected.

Key Words:

Apoptosis, Bcl-2, Brain, Cellular Phone, Electromag-

netic Waves, GSM, Histopat hology, Mobi le Phone,

P53, Rat.