Synthesis, spectroscopic and voltammetric studies of a novel Schiff-base of cysteine and saccharin

Cakir S., Odabasoglu M., Biçer E., Yazar Z.

JOURNAL OF MOLECULAR STRUCTURE, vol.918, no.1-3, pp.81-87, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 918 Issue: 1-3
  • Publication Date: 2009
  • Doi Number: 10.1016/j.molstruc.2008.07.015
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.81-87
  • Keywords: Schiff-base, Cysteine, Saccharin, Voltammetry, Spectroscopy, ADSORPTIVE STRIPPING VOLTAMMETRY, HUMAN-LEUKOCYTE ELASTASE, MERCURY-ELECTRODES, COMPLEXES, ACID, DERIVATIVES, BEHAVIOR, CU(II), IDENTIFICATION, INHIBITORS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this study, a novel Schiff-base of cysteine and saccharin [(2R)-2-(1, 1-dioxo-1, 2-dihydro-1 lambda 6-benzo[d]isothiazol-3-ylideneamino)-3-mercapto-propionic acid] was synthesized and characterized by UV-Vis, FT-IR, (1)H NMR and elemental analysis. The voltammetric behaviour of Schiff-base was investigated on the static mercury drop electrode (SMDE) by using Square-Wave voltammetry (SWV) and Cyclic voltammetry (CV). The voltammograms of the Schiff-base gave three reduction waves in Britton-Robinson buffer (pH 5.0-9.0) for the potential range from 0.0 to 1.4 V. The first reversible cathodic peak is due to reduction of the mercury thiolate, produced by the thiol group of Schiff-base which adsorbs at Hg electrode surface, to metallic mercury and free thiol. The second reduction peak may be assigned to the reduction of azomethine center (> C=N-) in the Schiff-base and the last peak may be related to the catalytic hydrogen reduction. (C) 2008 Elsevier B.V. All rights reserved.