Prognostic and diagnostic value of systemic inflammatory blood markers (NLR, MLR, PLR, AISI, SIRI, and SII) in feline arterial thromboembolism

Esin Ç., Uzun B.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, cilt.287, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 287
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.vetimm.2025.110980
  • Dergi Adı: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Feline Arterial Thromboembolism (FATE) is a challenging problem that requires urgent intervention. This study evaluated inflammatory markers' prognostic value in feline arterial thromboembolism (FATE), a devastating cardiac complication often necessitating euthanasia. We analysed inflammatory ratios (NLR, MLR, PLR, AISI, SIRI, SII) and echocardiographic measurements in FATE cats (n = 25) versus controls (n = 10). FATE patients demonstrated significantly elevated inflammatory markers and cardiac measurements. NLR showed strong correlation with cardiac parameters including LAMAX (r = 0.629), LA:Ao ratio (r = 0.489), IVSD (r = 0.422), and LVPWD (r = 0.607). Other inflammatory ratios similarly correlated with cardiac measurements. NLR emerged as the most accurate diagnostic biomarker (AUC = 1.000). Median survival time was 334 days overall. Cats with LAMAX >18 mm showed reduced survival (213 vs. 333 days). High NLR (>8) was associated with dramatically shortened survival (51 days) compared to moderate (5-8; 174 days) and low NLR (<5; 457 days). Elevated inflammatory markers (NLR >2, MLR >0.15, PLR >80, AISI >276, SIRI >1.08, SII >441) indicate poor prognosis. These accessible biomarkers may assist clinicians in emergency diagnosis confirmation and prognostication of FATE patients.