Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

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Köksal E., Karakaya D., Can Meydan B., Bozkurt A., Barış S., Bilge S. S., ...More

BALKAN MEDICAL JOURNAL, vol.30, no.4, pp.355-361, 2013 (SCI-Expanded, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.5152/balkanmedj.2013.7747
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.355-361
  • Keywords: Dexmedetomidine, analgesia, neurotoxicity, CLONIDINE, BUPIVACAINE, RECEPTOR, ANALGESIA, AGONISTS, COMPLICATIONS, PHARMACOLOGY, ANTAGONIST, BLOCKADE, EFFICACY
  • Open Archive Collection: AVESIS Open Access Collection
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Alpha 2 agonists contribute to pain control at the level of the medulla spinalis. Alpha 2 agonists are generally added to local anaesthetics to prolong spinal or epidural anaesthesia time.