Sedentary lifestyle, malnutrition and intense work hours resulting in high stress are challenging the human mind and psychology. Many people are genetically predisposed, but many, unfortunately, are unable to withstand this life and need professional support. Although technology is produced to make life easier, in practice it causes many people to live outside the border. Antidepressants, which are used as a result of professional support, benefit in the short term, but they cause serious damage to environmental and aquatic life on the invisible side of the iceberg due to personal waste, irregular use and overdose. If there is no follow-up and environmental removal, all non-target creatures other than humans will be damaged in a very short time, and hence this damage will return to the human being, like a boomerang. Although many methods have been developed for the treatment of these types of pollutants today, it is clear that new agents and methods should be developed that will enable mobile study in natural environment where the pollution emerges. Accordingly, the aim of this review is to make a critical analysis of studies on the determination, removal, and elimination of antidepressants in recent years and to inspire future studies.