The effect of prenatal exposure of a non-steroidal anti-inflammatory drug on the optic nerve of female rats: a stereological, histological, and electron microscopic study

Kaplan S., EŞREFOĞLU M., Aktas A., Gul M., Önger M. E., Altunkaynak M. E., ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.26, no.18, pp.1860-1864, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 18
  • Publication Date: 2013
  • Doi Number: 10.3109/14767058.2013.811227
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1860-1864
  • Keywords: Diclofenac sodium, electron microscopy, female rat, optic nerve, stereology, DICLOFENAC SODIUM, SPINAL-CORD, IN-VITRO, MORPHOLOGY, APOPTOSIS, NUMBER, HIPPOCAMPUS, QUINOLONES, DISECTOR, FIBERS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) can have adverse effects for in both mother and fetus following administration during the prenatal period. If given during pregnancy, diclofenac sodium (DS), an NSAID, is given during the pregnancy, may also affect the development of the central nervous system (CNS) or related structures.