There is a growing realization that an increasing number of countries are approaching full utilization of their conventional water resources and that the quantity of good-quality water supplies available to agriculture is diminishing. Effects of irrigation regime and irrigation water salinity on bell pepper including yield, fruit number and quality, vegetative and root growth, evapotranspiration and water use efficiency were investigated in this study by conducting two different experiments. Six different salinity levels of irrigation water and four different irrigation regimes were used as treatments. Considering the results from irrigation water salinity experiment, it can be concluded that as soil salinity increases, water consumption, water use efficiency, yield and other vegetative growth parameters of bell pepper were decreased. A polynomial relationship between soil salinity and water consumption was observed. It was found that bell pepper is moderately sensitive to salinity with a 1.2 dS m -1 threshold and a 10.9% slope value. In the irrigation regime experiment, limited irrigation caused decreases in water consumption, yield and vegetative growth of bell pepper. Yield response factors were close in the cases of irrigation regime (1.50) and irrigation water salinity (1.40). Total soluble solids of bell pepper were increased due to both irrigation water salinity and water application rate but not dry matter ratio. Considerable water consumption decreases because of salinity were determined. Therefore, the effect of irrigation water salinity should be considered in irrigation management to prevent excess saline water application and to protect the environment. © 2011 Taylor & Francis.