Vitamin B12 has important functions in cell cycle and it is essential for DNA synthesis and it plays a part in myelinisation and lipid metabolism of nervous system. Infantile nutritional megaloblastic anemia occurs due to both maternal and infantile causes. In here we presented three infants with megaloblastic anemia and who have different neurologic findings. Vitamin B12 deficiency causes different signs and symptoms but, the question that how much depth and length of vitamin B12 deficiency causes neurologic findings is not answered. We presented three infants with megaloblastic anemia caused by maternal and/or infantile causes and we want to emphasize neurologic manifestations. We observed that neurologic signs are independent from VB12 level. In a conclusion further animal experiments which explain the correlation between megaloblastic anemia and neurologic manifestations are needed.