An unusual case of an osteosarcoma arising in a leiomyoma of the uterus


Kefeli M., Baris S., Aydin O., Yıldız L., Yamak S., Kandemir B.

ANNALS OF SAUDI MEDICINE, vol.32, no.5, pp.544-546, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.5144/0256-4947.2012.23.5.1111
  • Journal Name: ANNALS OF SAUDI MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.544-546
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies.