Akademik Veri Yönetim Sistemi
Acta Medica Alanya, cilt.3, sa.3, ss.213-219, 2019 (Hakemli Dergi)
Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treatment of depression in pregnancy. However, there is little information on teratogeniceffects of selective serotonin reuptake inhibitors. This study aims to investigate the effects of prenatal exposure to citalopram, one of the most prescribed antidepressants,on developmental characteristics, reflex and motor functions of rat pups.Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were usedin the experiments. Rats were divided into 3 groups and separated into individual cages. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric gavage from gestational days 1 to 18, control group received the same amount of saline(2 ml/kg/d). After birth duration of gestation, number of live and dead pups and grossmalformation are evaluated. Eye opening, pinna detachment, incisor eruption, thedevelopment of fur and weight gain were monitored as developmental parameters.Markers for reflex development were identified as righting reflex, negative geotaxisand grip response. Motor developments and cognitive functions were establishedwith locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test.Results: Developmental parameters, reflex, motor and cognitive development assessments of pups were not significantly different in treatment groups compared tocontrol group.Conclusion: The results of the study show that prenatal exposure to citalopram hasno effect on motor and cognitive functions of rat offspring.