A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes

NURSAL A. F., YİĞİT S., Rustemoglu H., Cenikli A.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, vol.21, no.9, pp.1685-1690, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.2174/1568026620666201022144819
  • Journal Name: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1685-1690
  • Keywords: Sport performance, MTHFR, C677T, variant, sedentary, homocysteine (Hcy), HOMOCYSTEINE LEVELS, METHYLENETETRAHYDROFOLATE REDUCTASE, PHYSICAL PERFORMANCE, EXERCISE, POLYMORPHISM, STRENGTH, YOUNG, RISK, HOMOCYST(E)INE, ASSOCIATION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Increased level of plasma homocysteine (Hcy) is a potential risk factor for several multi-system diseases. The Methylenetetrahydrofolate reductase (MTHFR) gene C677T variant has been established as an important genetic determinant of hyperhomocysteinemia. There are conflicting reports about the effects of physical activity on plasma Hcy. Therefore, the main aim of this study was to investigate whether the MTHFR C677T variant affects elite athletic performance.