A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes

NURSAL A. F., YİĞİT S., Rustemoglu H., Cenikli A.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, cilt.21, sa.9, ss.1685-1690, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1568026620666201022144819
  • Dergi Adı: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1685-1690
  • Anahtar Kelimeler: Sport performance, MTHFR, C677T, variant, sedentary, homocysteine (Hcy), HOMOCYSTEINE LEVELS, METHYLENETETRAHYDROFOLATE REDUCTASE, PHYSICAL PERFORMANCE, EXERCISE, POLYMORPHISM, STRENGTH, YOUNG, RISK, HOMOCYST(E)INE, ASSOCIATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Increased level of plasma homocysteine (Hcy) is a potential risk factor for several multi-system diseases. The Methylenetetrahydrofolate reductase (MTHFR) gene C677T variant has been established as an important genetic determinant of hyperhomocysteinemia. There are conflicting reports about the effects of physical activity on plasma Hcy. Therefore, the main aim of this study was to investigate whether the MTHFR C677T variant affects elite athletic performance.