The effects of transient systemic hypotension on renal oxidative status, morphology and plasma nitric oxide levels in pregnant rats

Bayrak S., PEHLİVANOĞLU B., Balkanci Z. D., Ozyurek H., BAYAZIT Y., ATİLLA P., ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.22, sa.6, ss.528-536, 2009 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/14767050902822229
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.528-536
  • Anahtar Kelimeler: Hypotension, pregnancy, oxidative stress, renal injury, nitric oxide, BLOOD-PRESSURE, SUPEROXIDE-DISMUTASE, REPERFUSION INJURY, STRESS, ISCHEMIA, HEMODYNAMICS, HYPERTENSION, GLUTATHIONE, INHIBITION, MODULATION
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Objective. Transient hypotension attacks, frequently experienced during pregnancy, have detrimental effects on maternal and fetal physiology. Despite the strong autoregulatory mechanisms, kidneys are remarkably sensitive to hypoperfusion. Transient hypotension together with high metabolic demand and increased oxygen requirement during pregnancy may disturb the oxidant status and natural course of nitric oxide (NO) metabolism. Therefore, we investigated in this study the effects of systemic hypotension during pregnancy on kidney oxidant status and morphology and plasma NO levels in an experimental hypotension model in rats.