Association between sequence variations of the Mediterranean fever gene and fibromyalgia syndrome in a cohort of Turkish patients

KARAKUŞ N., YİĞİT S., İNANIR A., Inanir S., Toprak H., Okan S.

CLINICA CHIMICA ACTA, cilt.414, ss.36-40, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 414
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.cca.2012.07.019
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-40
  • Anahtar Kelimeler: Fibromyalgia, MEFV gene mutation, R202Q, DISEASE, POLYMORPHISM, MEFV, MUTATIONS, FREQUENCY, PREVALENCE, HAPLOTYPE, RECEPTOR, PYRIN
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Objective: Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Genetic risk factors are known to contribute to the etiology of the syndrome. Clinical features show that FMS and familial Mediterranean fever (FMF) have some overlapping symptoms. Mediterranean fever (MEFV) gene has already been identified as being responsible for FMF. The aim of this study was to explore the frequency and clinical significance of missense mutations and a common polymorphism of MEW gene in a cohort of Turkish patients with FMS.