A new trinuclear heterometallic nickel(II)-cadmium(II)-nickel(II) complex, [(NiL(NCS)(H2O))(2)Cd(DMF)(2)] (DMF: dimethylformamide) (1), has been synthesized by using NiL as the so-called metallo ligand where H2L = N,N-bis(salicylidene)-1,3-diaminopropane, cadmium nitrate, and amonium thiocyanate. The title complex was characterized by various methods including elemental analyses, IR, H-1-NMR, C-13-NMR, TG-DTA, and X-ray diffraction techniques. The complex crystallizes in monoclinic space group P2(1/c), with unit cell dimensions a = 10.6217(3), b = 13.3487(4), c = 16.0043(4) angstrom, = 93.823(2)degrees. The complex was screened for antimicrobial activities by the disc diffusion using DMF as solvent. The minimum inhibitory concentration values were calculated.