Serum Vitamin D Status and Outcome in Critically III Children

Creative Commons License

Asilioglu N., Cidem H., Paksu M. S.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE, sa.10, ss.660-664, 2017 (ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4103/ijccm.ijccm_153_17
  • Dergi Adı: INDIAN JOURNAL OF CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.660-664
  • Anahtar Kelimeler: 25-hydroxyvitamin D, illness severity, mortality, pediatric intensive care, D DEFICIENCY, POOR OUTCOMES, 25-HYDROXYVITAMIN-D, ASSOCIATION, MORTALITY, SEPSIS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Vitamin D is a pleiotropic hormone essential for optimal health. Critical illness in children is a major cause of significant health-care utilization and mortality around the world. The association of Vitamin D deficiency (VDD) in critically ill adults has been well-studied, in comparison, the importance of Vitamin D in pediatric critical illness has been much less studied. Aim and Objectives: This study aimed to assess Vitamin 1) status and its determinants in patients admitted to a pediatric intensive care unit (PICO in North of Turkey. We also investigated the association between Vitamin D status and clinical outcomes. Materials and Methods: All patients aged 1 month to 18 years admitted to the PICU or a tertiary care hospital who had levels of 25-hydroxy Vitamin D available within 24 h of admission were included in this retrospective study. VDD was defined as <20 ng/mL levels. Results: VDD was observed in 120 (58.5%) children. In multivariable linear regression model, only identified patient age and winter season as statistically associated with VDD. Vitamin D deficient patients were older and heavier and were more likely to receive catecholamine. There was no association between Vitamin D deficiency and other illness severity factors including mortality. Conclusions: llypovitaminosis D occurrence was high in critically ill children and was associated with higher vasopressor requirement but not with other markers of illness severity including mortality.