Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis

YİĞİT S., İNANIR A., Tekcan A., Tural E., ÖZTÜRK G., KISMALI G., ...Daha Fazla

GENE, cilt.537, sa.1, ss.6-9, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 537 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.gene.2013.12.060
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6-9
  • Anahtar Kelimeler: Knee osteoarthritis, Interleukin-4 (IL-4), Polymorphism, HAND OSTEOARTHRITIS, RECEPTOR, MECHANOTRANSDUCTION, CARTILAGE, VARIANTS, LOCUS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Interleukin-4 (IL-4) is a strong chondroprotective cytokine and polymorphisms within this gene may be a risk factor for osteoarthritis (OA). We aimed to investigate genotype and allele frequencies of IL-4 gene intron 3 variable number of tandem repeats (VNTR) polymorphism in patients with knee OA in a Turkish population.