Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis

YİĞİT, Serbülent; İNANIR, AHMET; Tekcan, Akin; Tural, Ercan; ÖZTÜRK, GÖKHAN; KISMALI, GÖRKEM; KARAKUŞ, NEVİN

doi:10.1016/j.gene.2013.12.060

Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis

YİĞİT S., İNANIR A., Tekcan A., Tural E., ÖZTÜRK G., KISMALI G., ...Daha Fazla

GENE, cilt.537, sa.1, ss.6-9, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 537 Sayı: 1
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.gene.2013.12.060
Dergi Adı: GENE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.6-9
Anahtar Kelimeler: Knee osteoarthritis, Interleukin-4 (IL-4), Polymorphism, HAND OSTEOARTHRITIS, RECEPTOR, MECHANOTRANSDUCTION, CARTILAGE, VARIANTS, LOCUS
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Interleukin-4 (IL-4) is a strong chondroprotective cytokine and polymorphisms within this gene may be a risk factor for osteoarthritis (OA). We aimed to investigate genotype and allele frequencies of IL-4 gene intron 3 variable number of tandem repeats (VNTR) polymorphism in patients with knee OA in a Turkish population.