Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis

YİĞİT S., İNANIR A., Tekcan A., Tural E., ÖZTÜRK G., KISMALI G., ...More

GENE, vol.537, no.1, pp.6-9, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 537 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.gene.2013.12.060
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6-9
  • Keywords: Knee osteoarthritis, Interleukin-4 (IL-4), Polymorphism, HAND OSTEOARTHRITIS, RECEPTOR, MECHANOTRANSDUCTION, CARTILAGE, VARIANTS, LOCUS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Interleukin-4 (IL-4) is a strong chondroprotective cytokine and polymorphisms within this gene may be a risk factor for osteoarthritis (OA). We aimed to investigate genotype and allele frequencies of IL-4 gene intron 3 variable number of tandem repeats (VNTR) polymorphism in patients with knee OA in a Turkish population.