Early creatinine and e-GFR changes as prognostic predictors of COVID-19 patients

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Ahmet K., Ebru C., Emre E., Aykut O., Yasemin K., Beyza S., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.47, sa.3, ss.237-245, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1515/tjb-2021-0201
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.237-245
  • Anahtar Kelimeler: COVID-19 disease, early prognosis, kidney involvement, laboratory parameters, mortality, bobrek tutulumu, COVID-19 hastaligi, erken donem prognoz, mortalite, ACUTE KIDNEY INJURY, DISEASE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Objectives We aimed to investigate the effects of the COVID-19 disease on kidney functions and early prognosis. Materials and Methods All cases were divided into those discharged and exitus cases. The patients were diagnosed with acute kidney injury (AKI) according to the KDIGO criteria. Results As a result of the ROC analysis, the patients with a creatinine value above 1.05 for day 1 and 0.975 for creatinine value on day 7 would be mortal (AUC values of 0.641 (0.569-0.714) and 0.757 (0.689-0.825), respectively). As a result of Univariate analysis; D-Dimer, Procalcitonin, BUN and creatinine values are risk factors and a one-unit increase in these values is 1.184; 1.105; It was determined that it would increase 1.024 and 1.304 times (p values 0.008; 0.007; <0.001; 0.002), respectively. Decreased in e-GFR value would increase the risk of death 1.026 (1/0.975) times (p<0.001). Conclusions We observed the high creatinine, D-dimer, procalcitonin, ferritin, and low e-GFR levels were risk factors for severity and mortality for COVID-19 disease. While physicians and all stakeholders focus on the prognosis and mortality of the disease of COVID-19 disease, it is necessary to be thorough about kidney involvement as much as respiratory system involvement.