Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups
ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.43, sa.5, ss.477-481, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 5
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.aller.2014.06.007
- Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.477-481
- Anahtar Kelimeler: Ataxia-telangiectasia, CD31, Immunodeficiency, Lymphocyte subpopulation, PECAM-1, Recent thymic emigrants, T-CELLS, CD4(+)
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background: Ataxia telangiectasia (A-T) is a genetic disorder caused by the homozygous mutation of the A-T mutated gene. It is frequently associated with variable degrees of cellular and humoral immunodeficiency. However, the immune defects in A-T patients are not well characterized. To the best of our knowledge, no studies have focused on the major lymphocyte subpopulations and recent thymic emigrants of A-T patients in comparison with age-matched healthy controls.