The Expression Frequency of Androgen Receptor, c-erbB2 and CD117 in Acinar Adenocarcinoma of Prostate and Normal Prostate Tissue and It's Clinical Importance
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, vol.14, no.4, pp.245-250, 2015 (ESCI)
- Publication Type: Article / Article
- Volume: 14 Issue: 4
- Publication Date: 2015
- Doi Number: 10.4274/uob.376
- Journal Name: UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI)
- Page Numbers: pp.245-250
- Keywords: Acinar adenocarcinoma of prostate, CD117, c-erbB2, androgen receptor, immuno-histochemistry
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Objective: In the cancer treatment, protein kinase inhibitors targeted at markers such as Her-2/neu (c-erbB2) and c-kit (CD117) are successful approaches. In this study, the expression of c-erbB2 and CD117 in normal prostate tissue as well as with low, moderate and high risk acinar adenocarcinoma of prostate with no androgen-suppression therapy, and, metastatic adenocarcinoma of prostate was investigated and the expression of androgen receptor (AR) was compared with c-erbB2 and CD117.