The Expression Frequency of Androgen Receptor, c-erbB2 and CD117 in Acinar Adenocarcinoma of Prostate and Normal Prostate Tissue and It's Clinical Importance
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, cilt.14, sa.4, ss.245-250, 2015 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 4
- Basım Tarihi: 2015
- Doi Numarası: 10.4274/uob.376
- Dergi Adı: UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.245-250
- Anahtar Kelimeler: Acinar adenocarcinoma of prostate, CD117, c-erbB2, androgen receptor, immuno-histochemistry
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Objective: In the cancer treatment, protein kinase inhibitors targeted at markers such as Her-2/neu (c-erbB2) and c-kit (CD117) are successful approaches. In this study, the expression of c-erbB2 and CD117 in normal prostate tissue as well as with low, moderate and high risk acinar adenocarcinoma of prostate with no androgen-suppression therapy, and, metastatic adenocarcinoma of prostate was investigated and the expression of androgen receptor (AR) was compared with c-erbB2 and CD117.