Synthesis and characterisations of some new 2,4-dihydro-[1,2,4]-triazol-3-one derivatives and X-ray crystal structures of 4-(3-phenylallylideneamino)-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol-3-one

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Sancak K., ÜNVER Y., Kazak C., Dugdu E., Arslan B.

TURKISH JOURNAL OF CHEMISTRY, vol.34, no.5, pp.771-780, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.3906/kim-0905-1
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.771-780
  • Keywords: 1,2,4-Triazole, aldehydes, ethyl bromoacetate, bromo acetophenone, X-ray crystallography, antimicrobial activity, SUBSTITUTED 1,2,4-TRIAZOLE, AROMATASE INHIBITORS, ANTIFUNGAL AGENTS, 1,3,4-THIADIAZOLE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Compounds 2 were synthesised via the reaction of 4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol- 3-one (1) with aldehydes. Compounds 3 and 4 were obtained from compounds 2 with bromo acetophenone and ethyl bromoacetate, respectively. The synthesis of compounds 2, 3, and 4 and crystal structure of compound 2a are being reported. The molecular structures were identified by IR, (1) H-NMR, C-13-NMR, MS, and elemental analyses. Compound 2a crystallises in the monoclinic P 21/n space group, with a = 6.565(5) angstrom, b = 18.278(5) angstrom, c = 13.8166(18) angstrom, beta = 96.227(5)., V = 1553.6(14) angstrom 3, Z = 4.