Stereoselective synthesis and discovery of novel spirooxindolopyrrolidine engrafted indandione heterocyclic hybrids as antimycobacterial agents

Arumugam N., Almansour A., Kumar R. S., Krishna V. S., Sriram D., DEGE N.

BIOORGANIC CHEMISTRY, vol.110, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 110
  • Publication Date: 2021
  • Doi Number: 10.1016/j.bioorg.2021.104798
  • Journal Name: BIOORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database, Index Chemicus (IC)
  • Keywords: Spirooxindolopyrroldines, Indandione, 1, 3-Dipolar cycloaddition, Ionic liquids, Anti-TB leads, CHOLINESTERASE INHIBITORY-ACTIVITY, TUBERCULOSIS, MULTICOMPONENT, DERIVATIVES, SCAFFOLDS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Novel spirooxindolopyrrolidine embedded indandione heterocyclic hybrids were obtained in excellent yields via a regio- and stereoselective one-pot three component reaction between Baylis-Hillman adduct and non-stabilized azomethine ylides. The structure of newly synthesized compounds was elucidated through 1D and 2D spectroscopic data and the stereochemistry was determined by single crystal X-ray diffraction analysis. In vitro tubercular activity against Mycobacterium tuberculosis H37Rv using MABA assay reveals that the compound bearing chlorine substituted on the oxindole ring displayed the most potent activity with MIC 0.78 ?g/mL and is two-fold active than the standard drug, ethambutol (MIC 1.56 ?g/mL).