Nonsurgical Periodontal Therapy Reduces Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis

Yucel Z. P. K., Keles G. C., Avcı B., Özkan Çetinkaya B.

ORAL HEALTH & PREVENTIVE DENTISTRY, vol.18, no.4, pp.815-822, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.3290/j.ohpd.a45086
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.815-822
  • Keywords: after-treatment, gingival crevicular fluid, human, interleukin-6, saliva, YKL-40 protein, EARLY RHEUMATOID-ARTHRITIS, REACTIVE PROTEIN-LEVELS, SERUM YKL-40, DISEASE, INTERLEUKIN-6, BIOMARKER, MARKER
  • Ondokuz Mayıs University Affiliated: Yes


Purpose: A novel acute-phase protein, YKL-40, is known as an inflammation-associated glycoprotein. YKL-40 is shown to be linked to inflammation, endothelial dysfunction and tissue remodeling secreted by various cells and is also considered to be stimulated by cytokines such as interleukin-6 (IL-6). The present study aimed to investigate YKL-40 and IL-6 levels in saliva and gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) after non-surgical periodontal therapy for the first time.