Novel metal complexes containing 6-methylpyridine-2-carboxylic acid as potent alpha-glucosidase inhibitor: synthesis, crystal structures, DFT calculations, and molecular docking

AVCI D., Alturk S., Sonmez F., Tamer O., BAŞOĞLU A., ATALAY Y., ...Daha Fazla

MOLECULAR DIVERSITY, cilt.25, sa.1, ss.171-189, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s11030-020-10037-x
  • Dergi Adı: MOLECULAR DIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.171-189
  • Anahtar Kelimeler: 6-Methylpyridine-2-carboxylic acid, Metal ions, XRD, FT-IR and UV&#8211, Vis, &#945, -Glucosidase, Docking, DFT, HSEh1PBE, DENSITY-FUNCTIONAL THEORY, NONLINEAR-OPTICAL-PROPERTIES, AB-INITIO, TRANSITION-METAL, PICOLINATE COMPLEXES, M(II) COMPLEXES, HARTREE-FOCK, II COMPLEX, IN-VITRO, SERIES
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The World Health Organization (WHO) report shows that diabetes mellitus (DM) will be one of the ten deadly diseases in the near future. The best way to prevent DM is to decrease blood glucose levels and keep under control; therefore, it is important to design and synthesize the effective inhibitors that can be used in the treatment of DM disease. In this respect, a series of ten metal complexes containing 6-methylpyridine-2-carboxylic acid {[Cr(6-mpa)(2)(H2O)(2)]center dot H2O center dot NO3, (1), [Mn(6-mpa)(2)(H2O)(2)], (2), [Ni(6-mpa)(2)(H2O)(2)]center dot 2H(2)O, (3), [Hg(6-mpa)(2)(H2O)], (4), [Cu(6-mpa)(2)(Py)], (5), [Cu(6-mpa)(2)(H2O)]center dot H2O, (6), [Zn(6-mpa)(2)(H2O)]center dot H2O, (7), [Fe(6-mpa)(3)], (8), [Cd(6-mpa)(2)(H2O)(2)]center dot 2H(2)O, (9), and [Co(6-mpa)(2)(H2O)(2)]center dot 2H(2)O, (10)} were synthesized as alpha-glucosidase inhibitors. We found that the IC50 values of the synthesized complexes ranged from 0.247 +/- 0.10 to > 600 mu M against alpha-glucosidase. The spectral analyses for these complexes characterized by XRD and LC-MS/MS were also carried out by FT-IR and UV-Vis spectra. Additionally, the DFT/HSEh1PBE/6-311G(d,p)/LanL2DZ level was applied to obtain optimal molecular geometries and spectral behaviors as well as significant contributions to the electronic transitions for the complexes. The molecular docking study was also performed to display interactions between the target protein (the template structure Saccharomyces cerevisiae isomaltase) and the synthesized complexes (1-10). Graphic abstract