In this study, we focused onthe fractal analysis, which has increasing interest and importance for spatial analysis and is integrated into Geographical Information Systems (GIS),and the spatio-temporal changes in land use/cover of Samsun province were determined by integration of GIS and fractal analysis. The spatial distribution and pattern of the land use/cover classes of Samsun province were determined by using the CORINE 2nd level land use/cover classes for 1990 and 2012, and the changes experienced in 1990-2012 period were examined. In fractal analyzes; fractal dimensions and lacunarity indexes were calculated by using the box counting and the gliding box algorithm, respectively. In the period of 1990-2012, considering 15 classes of CORINE level 2 data, both fractal dimension and lacunarity index increased in 2 classes, both fractal dimension and lacunarity index decreased in 1 class, fractal dimension increased and lacunarity index decreased in 4 classes, and fractal dimension decreased and lacunarity index increased in 8 classes. The results showed that examination of the degree of fragmentation/compactnessand heterogeneity/homogeneity, as well as the determination of surface area and spatial distributions, provides important information for the monitoring and evaluation of the environmental consequences of anthropogenic effects.