Crystallographic and spectroscopic characterization of 2-[(7-acetyl-4-cyano-6-hydroxy-1,6-dimethyl-8-phenyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-phenylacetamide

Al-Taifi, Elham; Maraei, Islam; Bakhite, Etify; Demirtas, Gunes; Mague, Joel; Mohamed, Shaaban; Ramli, Youssef

doi:10.1107/s2056989021000372

Crystallographic and spectroscopic characterization of 2-[(7-acetyl-4-cyano-6-hydroxy-1,6-dimethyl-8-phenyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-phenylacetamide

Al-Taifi E. A., Maraei I. S., Bakhite E. A., Demirtas G., Mague J. T., Mohamed S. K., ...Daha Fazla

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, cilt.77, ss.121-132, 2021 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 77
Basım Tarihi: 2021
Doi Numarası: 10.1107/s2056989021000372
Dergi Adı: ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
Sayfa Sayıları: ss.121-132
Anahtar Kelimeler: crystal structure, tetrahydroisoquinoline, phenylacetamide, hydrogen bond, C-H center dot center dot center dot pi(ring) interaction, ANALOGS
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In the title molecule, C28H27N3O3S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar and an intramolecular N-H center dot center dot center dot N hydrogen bond and a C-H center dot center dot center dot pi(ring) interaction help to determine the overall conformation. In the crystal, a layer structure with the layers parallel to (101) is generated by O-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds.